The best replacement for md80 is 737.

The best alternatives to md80 are rated as following:
★★★★★  737
★★★★  md90
★★★  757
★★  dc9
★★  717
★★  s80
★★  md83
★  boeing 737
★  veho muvi
  a319
  727
  737-800

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Google Trends

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md80
737
md90