The best replacement for lexus is250 is acura tsx.

The best alternatives to lexus is250 are rated as following:
★★★★★  acura tsx
★★★  audi a4
★★★  acura tl
★★★  bmw 328i
★★★  infiniti g35
★★  bmw 3 series
★★  bmw 325i
★  infiniti g37
★  infiniti g25
★  mercedes c250
  mercedes c300
  bmw 325
  mercedes c class
  bmw 320i
  g35
  bmw 320
  325i

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lexus is250
acura tsx
audi a4