The best replacement for lexus is 250 is acura tl.

The best alternatives to lexus is 250 are rated as following:
★★★★★  acura tl
★★★★★  acura tsx
★★★★  audi a4
★★★★  bmw 328i
★★★  infiniti g37
★  cla 250
★  mercedes c250
★  mercedes c300
  infiniti g25
  lexus is 350
  mercedes cla 250
  bmw 3 series
  volvo s60
  bmw 325

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lexus is 250
acura tl
acura tsx