The best replacement for kef q300 is focal 706v.

The best alternatives to kef q300 are rated as following:
★★★★★  focal 706v
★★★★★  monitor audio bx2
★★★★  685
★★★  paradigm studio 20
★★★  monitor audio rx2
★★  bx2
★★  psb image b6
★★  monitor audio rx1
★  polk rti a3
★  monitor audio bx5
★  b&w cm5
★  tannoy dc6
★  usher s520
  b&w 685

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Speaking about kef q300, one probably shouldn't forget about marantz pm6004.

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kef q300
focal 706v
monitor audio bx2