The best replacement for k9 advantix is frontline.

The best alternatives to k9 advantix are rated as following:
★★★★★  frontline
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★  advantix ii
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★  advantage ii
★  trifexis
★  comfortis
★  vectra 3d
★  k9 advantix ii
★  k9 advantix 2
  advantix
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  first shield trio
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  k9 advantix ll
  vetguard plus
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  k9 advantage

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Speaking about k9 advantix, one probably shouldn't forget about sentinel.

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