The best replacement for isco is gotze.

The best alternatives to isco are rated as following:
★★★★★  gotze
★★★★★  modric
★★★★★  ozil
★★★★  oscar
★★★  thiago
★★  jese
★  eriksen
★  muniain
★  thiago alcantara
★  rodriguez
★  koke
★  draxler
  james rodriguez
  di maria

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Google Trends

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isco
gotze
modric