The best replacement for irritation is pink eye.

The best alternatives to irritation are rated as following:
★★★★★  pink eye
★★★★★  std
★★★★  herpes
★★★★  allergy
★★★  annoyance
★★★  inflammation
★★  sensitization
★  annoyance to
★  allergic reaction
★  yeast infection
  eye infection

Your alternative for irritation is not listed? Suggest!
Speaking about irritation, one probably shouldn't forget about redness.

Other search terms related to irritation and their ratings are:
★★★★★ redness
★★★ shaving
You have in mind a companion for irritation and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of irritation in all years. Click on graph for more.
irritation
pink eye
std