The best replacement for hotwire is priceline.

The best alternatives to hotwire are rated as following:
★★★★★  priceline
★★★★  expedia
★★★  travelocity
★★  orbitz
★  kayak
★  priceline bid
★  booking.com
  priceline better
  hotels com
  hotels.com
  priceline cheaper
  priceline cars
  expedia better
  neutrino

Your alternative for hotwire is not listed? Suggest!
Speaking about hotwire, one probably shouldn't forget about bill me later.

Other search terms related to hotwire and their ratings are:
★★★★★ bill me later
You have in mind a companion for hotwire and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of hotwire in all years. Click on graph for more.
hotwire
priceline
expedia