The best replacement for hashirama senju is kakuzu.

The best alternatives to hashirama senju are rated as following:
★★★★★  kakuzu
★★★★★  hiruzen sarutobi
★★★★★  uchiha madara
★★★  madara uchiha ova
★★  madara uchiha
★★  tobirama senju
  uchiha

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hashirama senju
kakuzu
hiruzen sarutobi