The best replacement for hand cannon is crystal bow.

The best alternatives to hand cannon are rated as following:
★★★★★  crystal bow
★★★★★  pipe shotgun
★★★  dark bow
★★★  black salamander
★★★  royal crossbow
★★★  chicago typewriter
★★  volley gun
★★  chaotic crossbow
★★  rune crossbow
★  pistol bioshock infinite
★  armadyl crossbow
  zaryte bow

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hand cannon
crystal bow
pipe shotgun