The best replacement for gtx295 is 4870x2.

The best alternatives to gtx295 are rated as following:
★★★★★  4870x2
★★★  gtx280
★★  gtx480
★★  gtx285
★★  5870
★★  hd5870
★  9800gx2
  hd4870x2

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gtx295
4870x2
gtx280