The best replacement for glock 22 is 23.

The best alternatives to glock 22 are rated as following:
★★★★★  23
★★★  glock 23
★★  35
★★  glock 17
★★  17
★★  21
★  glock 21
★  m&p 40
★  glock 35
★  glock 19
★  sig p226
★  23 gen 4
★  xd 40
★  glock 22c
  springfield xd 40
  s&w m&p 40
  22c
  mp40
  beretta px4
  smith and wesson m&p 40
  sd40ve
  springfield xd
  sig p229
  glock 31
  xd40
  m p 40
  smith and wesson m&p
  31
  springfield xdm 40

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glock 22
23
glock 23