The best replacement for excel 2000 is excel 2003.

The best alternatives to excel 2000 are rated as following:
★★★★★  excel 2003
★★★  excel 2007
★  excel 97

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Speaking about excel 2000, one probably shouldn't forget about xlsx.

Other search terms related to excel 2000 and their ratings are:
★★★★★ xlsx
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