The best replacement for essence is existence.

The best alternatives to essence are rated as following:
★★★★★  existence
★★★★  extract
★★  serum
★★  vanilla extract
★★  accident
★  elite
★  easy clean
★  emulsion
★  essential oil
★  ceremony
★  existence descartes
★  flexcare
  essence
  substance
  clarisonic
  essiac
  energies
  bare minerals
  aussie
  dermanew
  woodclad
  in a sense
  catrice
  xtreme
  almond extract
  neutrogena microdermabrasion
  pantene

Your alternative for essence is not listed? Suggest!
Speaking about essence, one probably shouldn't forget about existence.

Other search terms related to essence and their ratings are:
★★★★★ existence
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Google Trends

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essence
existence
extract