The best replacement for efudex is aldara.

The best alternatives to efudex are rated as following:
★★★★★  aldara
★★★★  carac
★★★  zyclara
★★  solaraze
★★  photodynamic therapy
★★  picato
★  fluorouracil
★  imiquimod
★  efudix
★  levulan
★  fluoroplex
  pdt
  carac cream
  curaderm
  mohs
  blue light

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efudex
aldara
carac