The best replacement for diphenhydramine hydrochloride is diphenhydramine citrate.

The best alternatives to diphenhydramine hydrochloride are rated as following:
★★★★★  diphenhydramine citrate
★★★  loratadine
★★  diphenhydramine
★★  hydrocortisone
★★  doxylamine succinate
★  dimenhydrinate
★  diphenhydramine hci
★  citrate
★  chlorpheniramine maleate

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diphenhydramine hydrochloride
diphenhydramine citrate
loratadine