The best replacement for despicable me is megamind.

The best alternatives to despicable me are rated as following:
★★★★★  megamind
★★★★★  despicable me 2
★★★★  toy story 3
★★★★  martin garrix
★★★  monsters university
★★  monsters inc
★  tangled

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despicable me
megamind
despicable me 2