The best replacement for despair is integrity.

The best alternatives to despair are rated as following:
★★★★★  integrity
★★★★  hope
★★★  kunai
★★  desperation
★★  ego integrity
★  hikou
★  generativity
★  hopelessness
★  wisdom
★  integrity examples
  integrity stage
  desperate
  despair

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Google Trends

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