The best replacement for desktop application is web application.

The best alternatives to desktop application are rated as following:
★★★★★  web application
★★  mobile application
★  enterprise application
  windows application
  web based application
  web

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No companions for desktop application have been suggested so far.
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Google Trends

Scale is based on the average worldwide traffic of desktop application in all years. Click on graph for more.
desktop application
web application
mobile application