The best replacement for depp is brad pitt.

The best alternatives to depp are rated as following:
★★★★★  brad pitt
★★★★★  orlando bloom
★★★  tom cruise
★★  wilder
★★  leonardo dicaprio
★★  gene wilder
★  robert downey jr
★  bloom
★  richard grieco
★  george clooney
★  ian somerhalder
★  pitt
  keanu reeves
  sean penn
  robert pattinson
  angelina jolie

Your alternative for depp is not listed? Suggest!
Speaking about depp, one probably shouldn't forget about amber heard.

Other search terms related to depp and their ratings are:
★★★★★ amber heard
★★★★★ black keys
★★★★★ marilyn manson
★★★ aerosmith
★★★ angelina jolie
★★ ricky gervais
★★ ashley olsen
★ winona ryder
★ kate moss
★ david letterman
★ alice cooper
vanessa paradis
tim burton
leonardo dicaprio
You have in mind a companion for depp and it is not yet here? Propose!



Google Trends

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depp
brad pitt
orlando bloom