The best replacement for defrag is cleanup first.

The best alternatives to defrag are rated as following:
★★★★★  cleanup first
★★★★  disk cleanup first
★★★★  disk cleanup
★★★★  optimize
★★★  format
★★★  auslogics
★★★  reindex
★★  scandisk first
★★  check disk first
★★  not to defrag
★★  quick defrag
★★  rebuild index
★  scandisk
★  cleanup
★  rebuild indexes
★  chkdsk
★  reformat
★  speed disk
★  scan disk first
★  diskeeper
★  smart defrag
★  mydefrag
★  defraggler
★  windows defrag
★  perfectdisk
  defrag
  ultradefrag
  disc cleanup
  perfect disk
  disc clean up
  scan disk
  clean up
  iobit smart defrag
  norton speed disk
  auslogics defrag

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Google Trends

Scale is based on the average worldwide traffic of defrag in all years. Click on graph for more.
defrag
cleanup first
disk cleanup first