The best replacement for cosopt is combigan.

The best alternatives to cosopt are rated as following:
★★★★★  combigan
★★★★  cosopt pf
★★★  timolol
★★  azarga
★★  azopt
★★  cosopt plus
★★  xalacom
★★  xalatan
★  combign
★  trusopt
★  latanoprost
  alphagan

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cosopt
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cosopt pf