The best replacement for brimonidine is apraclonidine.

The best alternatives to brimonidine are rated as following:
★★★★★  apraclonidine
★★★★  alphagan p
★  bimatoprost
★  alphagan
★  brinzolamide

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No companions for brimonidine have been suggested so far.
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Google Trends

Scale is based on the average worldwide traffic of brimonidine in all years. Click on graph for more.
brimonidine
apraclonidine
alphagan p