The best replacement for blessed thistle is milk thistle.

The best alternatives to blessed thistle are rated as following:
★★★★★  milk thistle
★★★  fenugreek

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Speaking about blessed thistle, one probably shouldn't forget about fenugreek.

Other search terms related to blessed thistle and their ratings are:
★★★★★ fenugreek
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blessed thistle
milk thistle
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