The best replacement for audi s4 is bmw m3.

The best alternatives to audi s4 are rated as following:
★★★★★  bmw m3
★★★★  bmw 335i
★★★  m3
★★  335i
★  bmw 335xi
★  lexus isf
★  bmw 335
★  infiniti g37
  lexus is350
  bmw 535i
  cla 45 amg
  subaru sti
  bmw 435i
  bmw 335i 2012
  audi s5
  subaru wrx
  mercedes c63
  c63 amg
  infiniti q50
  bmw 335i xdrive
  amg c63
  bmw m5
  audi a6
  bmw 335i 2011
  porsche cayman s
  bmw 335d

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Google Trends

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audi s4
bmw m3
bmw 335i