The best replacement for appscan is fortify.

The best alternatives to appscan are rated as following:
★★★★★  fortify
★★★★  acunetix
★★★  burp
★★★  veracode
★★  nessus
★★  qualys
★  webinspect
★  netsparker
★  hp webinspect

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appscan
fortify
acunetix