The best replacement for anime studio is toon boom.

The best alternatives to anime studio are rated as following:
★★★★★  toon boom
★★★  adobe flash
★★  manga studio
★★  poser
★★  crazytalk animator
★  synfig
★  motion artist
  flash cs6
  toon boom studio
  synfig studio
  crazytalk
  toonboom

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Speaking about anime studio, one probably shouldn't forget about poser.

Other search terms related to anime studio and their ratings are:
★★★★★ poser
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Google Trends

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anime studio
toon boom
adobe flash