The best replacement for alka seltzer is tums.

The best alternatives to alka seltzer are rated as following:
★★★★★  tums
★★★★  nyquil
★★★  pepto bismol
★  picot
★  alka seltzer gold
★  seagulls
★  mentos
★  pepto
★  rolaids
★  bromo seltzer
★  eno
  theraflu
  andrews salts
  dayquil
  mucinex

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Google Trends

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alka seltzer
tums
nyquil