The best replacement for acura mdx is rdx.

The best alternatives to acura mdx are rated as following:
★★★★★  rdx
★★★★★  honda pilot
★★★★  bmw x5
★★★  lexus rx
★★  toyota highlander
★★  audi q7
★★  audi q5
★★  volvo xc90
★★  lexus rx 350
★  infiniti qx60
★  ford explorer
★  lexus gx
★  honda odyssey
★  buick enclave
★  jeep grand cherokee
★  bmw x3
★  infiniti jx
★  lexus rx350
  toyota highlander limited
  gmc acadia
  x5
  porsche cayenne
  bmw x5 2014
  audi q7 2014
  mercedes ml350
  nissan murano
  lexus rx330
  infiniti fx35
  mazda cx9
  cadillac srx
  lexus 350
  lexus rx300
  volvo xc60
  mercedes gl
  acura rdx
  4runner
  lexus gx 470
  ml350
  acura mdx touring
  lexus
  highlander 2014
  2011 ford explorer
  lexus gx470
  infiniti fx
  lincoln mkx
  rx 350
  enclave
  mdx touring
  ford edge
  odyssey
  mazda cx-9
  toyota 4runner

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Google Trends

Scale is based on the average worldwide traffic of acura mdx in all years. Click on graph for more.
acura mdx
rdx
honda pilot