The best replacement for 50ae is 44 mag.

The best alternatives to 50ae are rated as following:
★★★★★  44 mag
★★★  454 casull
★★★  10mm
★★  50 gi
★★  460 s&w
★★  500s&w
★  50 s&w
★  500 s&w
★  s&w 500
★  480 ruger
★  500 magnum
  44 magnum
  44mag
  475 wildey
  .500 mag
  50s&w

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50ae
44 mag
454 casull