The best replacement for 50 ae is 44 mag.

The best alternatives to 50 ae are rated as following:
★★★★★  44 mag
★★★★  500 s&w
★★★  454 casull
★★★  500 magnum
★★  50 gi
★  50 beowulf
★  480 ruger
★  .500 smith and wesson
★  44 magnum
★  454
★  50 bmg
  .460 rowland

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50 ae
44 mag
500 s&w