The best replacement for 4850 crossfire is 4850x2.

The best alternatives to 4850 crossfire are rated as following:
★★★★★  4850x2

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Speaking about 4850 crossfire, one probably shouldn't forget about 4870.

Other search terms related to 4850 crossfire and their ratings are:
★★★★★ 4870
★★ 6850
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4850 crossfire
4850x2