The best replacement for .22lr is .223.

The best alternatives to .22lr are rated as following:
★★★★★  .223
★★★★  .17hmr
★★★  .22 wmr
★★★  .22
★★  .25acp
★★  .380
★★  .22 mag
★★  .22 magnum
★  .17
★  .22 hornet
★  .25
★  .22mag
★  .22 rimfire
★  .22 air rifle
  .32
  .22 mini mag

Your alternative for .22lr is not listed? Suggest!
Speaking about .22lr, one probably shouldn't forget about suppressor.

Other search terms related to .22lr and their ratings are:
★★★★★ suppressor
You have in mind a companion for .22lr and it is not yet here? Propose!



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.22lr
.223
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